Back

DrosophilaClockLogo.png
Location
Anywhere
Date Posted
4 Jul 2018

Visit website


Type
PhD Project
Tauber research laboratory for Biological Clocks

PhD position in Functional Genomics

DrosophilaClockLogo.png
Anywhere
4 Jul 2018

NOTE: this position listing has expired and may no longer be relevant!

Position Description


Scholarships for graduate students are now available at the Tauber research laboratory for Biological Clocks at the University of Haifa, Israel. Research in the lab focuses on the the circadian clock: a fascinating system that drives daily rhythms in physiology, metabolism and behaviour, and is present in nearly all living organisms. We study Drosophila, whose clock genes are well conserved in humans. We employ a broad range of techniques, including molecular cloning, transgenics and imaging, as well as quantitative genetics, behavioural analysis, and bioinformatics.

Circadian clocks are molecular pacemakers in the brain and are present in diverse range of organisms, from cyanobacteria to human. The rhythm of the endogenous clock (slightly different from 24hr) is adjusted to the solar day by entrainment to various stimuli, primarily light. Modern life introduces situations, such as transatlantic flights and shift work, where the circadian rhythm and the external light cycle are too dissimilar to reconcile leading to a wide range of health problems, including ‘jetlag’, sleep disorders, seasonal depression, and cancer.

In the last few decades, the molecular basis of the clock has been elucidated. The fruit-fly Drosophila has been a major model system for identifying circadian clock genes, which are well conserved in human. By inducing mutagenesis and screening for Drosophila mutants that show aberrant light response, various proteins were identified to be involved in light transduction. Our research focuses on natural genetic variation related to clock function. We aim at identifying natural variants that have been evolved in wild populations, serving as molecular adaptations under different light and temperature conditions. We use broad range of techniques, including molecular cloning, transgenics and gene knockdown as well as quantitative genetics, behavioural analysis, and bioinformatics.

Potential Research Projects:

1) Study how natural genetic variations in clock genes modify the clock function in different environments.

2) Study what is the role of the circadian clock in dey-length measurement (the photoperiodic clock), which is important for timing seasonal responses (for this area of research we are also using the Jewel wasp Nasonia as model system).

3) Study the genetic basis that underlies preference for either diurnal or nocturnal activity in animals.

For more information Visit our website: www.bit.ly/tauberLab


How to Apply

Candidates should have an excellent B.Sc degree in biosciences or computer science. Previous experience in any o fthe following fields is desirable: molecular biology, drosophila genetics, bioinformatics, chronobiology. Please send a cover letter, a CV and a reference list to Prof. Eran Tauber eran.tauber@gmail.com. Selected candidates will be interviewed.

Position Category: Medical & Biological Sciences. Position Type: PhD Project.

Apply online


Upload your CV (optional)

Upload your Cover Letter (optional)


This is to prevent spam: