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Location
Anywhere
Date Posted
6 Feb 2020

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Type
PhD Project
Infinite U1286, Univ. Lille/Inserm/CHU Lille

PhD candidate

Anywhere
6 Feb 2020

Position Description


Identification of a new molecular target in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a serious and incurable disease, with increasing frequency, characterized by a progressive and irreversible loss of respiratory abilities with a median survival of 3 to 5 years after diagnosis. The only two anti-fibrotic molecules available on the market in IPF limit the progression of the disease but have a very modest impact on survival.
We developed an interleukin-13 pulmonary fibrosis induction model on air/liquid interface (ALI) cultures of mouse lungs and identified a new and specific therapeutic target in IPF. The thesis project involves characterizing induced fibrosis using molecular approaches and imaging techniques and validating the molecular target using a shRNA approach.
The expected results of validating the molecular target with this model are to define original therapeutic strategies to inhibit/block fibrosis in IPF.


How to Apply

The International Selection recruits outstanding candidates who are eager to be involved in a research- based academic curriculum in Lille. Non-French PhD candidates are identified by the research unit and qualified students from abroad are proposed by the research unit for the selection. For the academic year 2020/2021, the Doctoral School is offering research fellowships fully funded by the University of Lille for foreign students to attend Doctoral Courses. The duration of the doctoral courses is three years, starting October 2020 and ending September 2023. In order to be deemed eligible, applicants are required to meet the following criteria by the deadline date of the call: - to have obtained or to prepare a foreign (non-French) academic qualification recognized as equivalent to the Master à parcours recherche amounting to at least five years of full time university education and leading to a PhD in the country where the studies were carried out. The eligible degree must be awarded no later than September 30 th , 2020; - to have never been enrolled in the French academic system for any degree Candidates will be admitted to the selection procedure with reserve. Applications must be submitted by the Research Unit/Team by March 15th, 2020. Candidates who pass the pre-selection process, and considered eligible, will be evaluated by a jury on their scientific excellence. Interviews will be conducted by video conferencing at the end of April 2020. Interested candidates must first send a CV+letter to jean-luc.desseyn@inserm.fr

Position Category: Medical & Biological Sciences. Position Type: PhD Project.

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