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Location
Lille
Hauts-de-France, France
Date Posted
30 Jan 2018

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Type
PhD Project
Université Lille/Inserm/CHU LIlle

PhD candidate

Lille
Hauts-de-France, France
30 Jan 2018

Position Description


Gel-forming mucins are large and mosaic O-glycosylated molecules that constitute the framework of mucus hydrogels. The highly conserved CYS domain found in many mucins may crosslink mucin fibers to strengthen the mucin network and the mucosal barrier. Our aim is to show that recombinant molecules made of consecutive copies of the CYS domain secreted by a transgenic mouse line, by a mucus-secreting cell line and by a yeast strain reinforce the mucus barrier which will be microrheologically evaluated by analyzing particle dynamics (diffusion, sedimentation and/or confinement) and cell motility. The Proof of Concept that molecules made of CYS domains strengthen the mucus layer will be translated to an experimental mouse model of infection. We will demonstrate that recombinant molecules favor the mucus colonization with probiotic lactobacilli. Our results will empower to conceive scientific solutions in health for diseases linked to dysbiosis.


How to Apply

International Selection for foreign PhD candidates In order to be deemed eligible, applicants are required to meet the following criteria by the deadline date of the call: - to have obtained or to prepare a foreign (non-French) academic qualification recognized as equivalent to the Master à parcours recherche amounting to at least five years of full time university education and leading to a PhD in the country where the studies were carried out. The eligible degree must be awarded no later than September 30 th , 2018; - to have never been enrolled in the French academic system for any degree Applications will be submitted by the Principal Investigator to the doctoral school by e-mail by 06.00 p.m. (French local time) of the deadline date (March 14 th , 2018). The complete application file includes the following documents: - the identification form, a thesis proposal (original research plan - 6 pages maximum, in French or English), written by the PI in agreement with the PhD candidate - the candidate files, in French or English, including : o a detailed Curriculum Vitae, o an identity document, o a covering letter, o the description of the academic degrees, with the indication of when and from which university it was/will be awarded; o scanned copies of the certificates of the academic qualifications with the list of the examinations and marks. any additional information that might support the request for academic equivalency of candidate French Master degree (mainly for Master or other diploma from outside the European Union) such as : Ms thesis, publications, official document specifying that the diploma gives access to the PhD in the country where the qualification was issued,... The application must be completed in French or English. All attached documents must be in French or English, or accompanied by a translation in French or English. Candidates who pass the pre-selection process, and considered eligible, will be evaluated by a jury on their scientific excellence. The best applicants will be competitively selected and a maximum of eight interviews will be conducted by the jury by video conferencing. Interviews will take place on 29 th March 2018. The jury will consist in  6 experts for each thematic fields of the Doctoral School (cancer, cardiovascular and metabolism diseases, infection - inflammation and immunity, neurosciences, drug science, glycobiology),  3 judging coordinators and  the Vice President for Research of the university that fund the grants or his designated representative. A research grant will be awarded to the first candidates in the ranking, subject of passing their Master degree or equivalent. Candidates must first send a CV+letter to jean-luc.desseyn@inserm.fr

Position Category: Medical & Biological Sciences. Position Type: PhD Project. Salary: €30'000 - €40'000.

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