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Location
Bordeaux
Aquitaine, France
Date Posted
8 Jan 2017

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Type
PhD Project
Inserm / Univ. Bordeaux

Biophysics / Mass Spectrometry / RNA Research

Bordeaux
Aquitaine, France
8 Jan 2017

NOTE: this position listing has expired and may no longer be relevant!

Position Description


Research topic: Characterizing structural and energetic aspects of RNA aptamer binding to metabolites, using mass spectrometry-based methodologies. Ligand binding is intimately linked to conformational rearrangements in the RNA. We will therefore combine mass spectrometry detection of the complexes with ion mobility spectrometry analysis, to reveal these conformational changes. The newly developed methods can help screening RNA libraries with regard to ligand binding, or to screen small molecule libraries with regard to binding to a specific RNA sensor.

The team of Valérie Gabelica is specialized in mass spectrometry of intact nucleic acid structures and their complexes with cations and ligands: http://www.iecb.u-bordeaux.fr/teams/GABELICA/. For more information about this position, please contact valerie.gabelica@inserm.fr.

Doctoral Training: the fellow will belong to the Marie Sklodowska Curie ITN (Initial Training Network) MetaRNA. As a PhD student in an ITN network, you will have – as any other “normal” PhD student – a host lab, where you will be doing your research. ITNs are financially supported by the European Commission because they provide excellent research, training and career aspects (which is something that is sometimes not guaranteed when doing a “normal” PhD). Thus, there a number of benefits being a PhD student in an ITN (see http://metarna.eu/benefits-of-doing-a-phd-within-an-itn-project/).

Recruiting organization: Institut National de la Santé et de la Recherche Médicale (Inserm), U869 unit « ARNA – Artificial and Natural Regulation of Nucleic Acids »

Workplace: Institut Européen de Chimie et Biologie – Bordeaux – FRANCE

Desired background: Master’s degree training in at least one of the following: Physical, analytical, or supramolecular chemistry – Biophysics – Mass spectrometry – Biochemistry. English is mandatory.


How to Apply

Application procedure: Applications should be submitted online to http://metarna.eu. 25 candidates (for the 15 positions) will be invited to recruitments days in Amsterdam (11./12.03.15), where all group leaders will be present. A decision will be made mid of March. Starting dates will be in summer 2015. Deadline: Feb. 7, 2015

Position Category: Chemical Sciences. Position Type: PhD Project. Salary: €30'000 - €40'000.

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